256988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2864056..2864719 Replicon chromosome
Accession NZ_CP104006
Organism Yersinia alsatica strain SCPM-O-B-7604

Toxin (Protein)


Gene name tad Uniprot ID A0A0T9T9C7
Locus tag N0H69_RS12740 Protein ID WP_050152171.1
Coordinates 2864375..2864719 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag N0H69_RS12735 Protein ID WP_050135326.1
Coordinates 2864056..2864373 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0H69_RS12700 (N0H69_12700) 2860251..2860685 - 435 Protein_2482 phage tail protein -
N0H69_RS12705 (N0H69_12705) 2860896..2861210 + 315 WP_050152175.1 hypothetical protein -
N0H69_RS12710 (N0H69_12710) 2861411..2861707 - 297 WP_050152174.1 NadS family protein -
N0H69_RS12715 (N0H69_12715) 2861782..2862099 - 318 WP_050121413.1 type II toxin-antitoxin system RelE/ParE family toxin -
N0H69_RS12720 (N0H69_12720) 2862240..2862440 - 201 WP_050152173.1 hypothetical protein -
N0H69_RS12725 (N0H69_12725) 2863010..2863195 - 186 WP_050152172.1 transposase -
N0H69_RS12730 (N0H69_12730) 2863241..2863429 - 189 WP_050135328.1 hypothetical protein -
N0H69_RS12735 (N0H69_12735) 2864056..2864373 - 318 WP_050135326.1 helix-turn-helix transcriptional regulator Antitoxin
N0H69_RS12740 (N0H69_12740) 2864375..2864719 - 345 WP_050152171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0H69_RS12745 (N0H69_12745) 2865956..2866155 + 200 Protein_2491 hypothetical protein -
N0H69_RS12750 (N0H69_12750) 2866385..2868145 + 1761 Protein_2492 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flmH 2619139..2972621 353482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12552.42 Da        Isoelectric Point: 9.7663

>T256988 WP_050152171.1 NZ_CP104006:c2864719-2864375 [Yersinia alsatica]
MKPLYWVGSSKKDLQSLPEDVQDIFGYGLHLSQMGGKHSQAKPLKGFGGAGVLEVVEDYIGETYRAVYTVKFGHAVYVLH
AFQKKSSSGITTPKPDMDKIRERLKIAESHAKGA

Download         Length: 345 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11511.43 Da        Isoelectric Point: 10.6107

>AT256988 WP_050135326.1 NZ_CP104006:c2864373-2864056 [Yersinia alsatica]
MSHDIEASSGNIYADLGKENAEEMQVKAQLATTIGNIIKGRRLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVVFA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9T9C7

Antitoxin

Source ID Structure

References