Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1673460..1674257 Replicon chromosome
Accession NZ_CP104001
Organism Enterobacter roggenkampii strain RX.G5M56

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag N0B38_RS07745 Protein ID WP_032651255.1
Coordinates 1673736..1674257 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag N0B38_RS07740 Protein ID WP_008499829.1
Coordinates 1673460..1673729 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0B38_RS07710 (N0B38_07710) 1668720..1669256 - 537 WP_135346066.1 OmpH family outer membrane protein -
N0B38_RS07715 (N0B38_07715) 1669681..1670922 + 1242 WP_135346067.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
N0B38_RS07720 (N0B38_07720) 1670956..1671183 - 228 WP_008499832.1 YccJ family protein -
N0B38_RS07725 (N0B38_07725) 1671204..1671800 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
N0B38_RS07730 (N0B38_07730) 1672192..1672362 + 171 WP_013097201.1 general stress protein -
N0B38_RS07735 (N0B38_07735) 1672481..1673398 + 918 WP_025912980.1 DMT family transporter -
N0B38_RS07740 (N0B38_07740) 1673460..1673729 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
N0B38_RS07745 (N0B38_07745) 1673736..1674257 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
N0B38_RS07750 (N0B38_07750) 1674331..1675653 - 1323 WP_104948907.1 pyrimidine utilization transport protein G -
N0B38_RS07755 (N0B38_07755) 1675675..1676169 - 495 WP_023327078.1 pyrimidine utilization flavin reductase protein F -
N0B38_RS07760 (N0B38_07760) 1676179..1676769 - 591 WP_106106141.1 malonic semialdehyde reductase -
N0B38_RS07765 (N0B38_07765) 1676779..1677579 - 801 WP_106106140.1 pyrimidine utilization protein D -
N0B38_RS07770 (N0B38_07770) 1677587..1677973 - 387 WP_008499822.1 pyrimidine utilization protein C -
N0B38_RS07775 (N0B38_07775) 1677985..1678674 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T256973 WP_032651255.1 NZ_CP104001:1673736-1674257 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT256973 WP_008499829.1 NZ_CP104001:1673460-1673729 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References