Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1069596..1070216 Replicon chromosome
Accession NZ_CP104001
Organism Enterobacter roggenkampii strain RX.G5M56

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag N0B38_RS04915 Protein ID WP_008499287.1
Coordinates 1069596..1069814 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag N0B38_RS04920 Protein ID WP_008499288.1
Coordinates 1069842..1070216 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0B38_RS04885 (N0B38_04885) 1065609..1065869 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
N0B38_RS04890 (N0B38_04890) 1065872..1066012 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N0B38_RS04895 (N0B38_04895) 1066009..1066719 - 711 WP_135345885.1 GNAT family protein -
N0B38_RS04900 (N0B38_04900) 1066821..1068281 + 1461 WP_008499284.1 PLP-dependent aminotransferase family protein -
N0B38_RS04905 (N0B38_04905) 1068253..1068720 - 468 WP_059362219.1 YlaC family protein -
N0B38_RS04910 (N0B38_04910) 1068838..1069389 - 552 WP_045416680.1 maltose O-acetyltransferase -
N0B38_RS04915 (N0B38_04915) 1069596..1069814 - 219 WP_008499287.1 HHA domain-containing protein Toxin
N0B38_RS04920 (N0B38_04920) 1069842..1070216 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
N0B38_RS04925 (N0B38_04925) 1070726..1073872 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
N0B38_RS04930 (N0B38_04930) 1073895..1075088 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T256972 WP_008499287.1 NZ_CP104001:c1069814-1069596 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT256972 WP_008499288.1 NZ_CP104001:c1070216-1069842 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References