Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 596694..597273 Replicon chromosome
Accession NZ_CP104001
Organism Enterobacter roggenkampii strain RX.G5M56

Toxin (Protein)


Gene name shpA Uniprot ID A0A656ULU9
Locus tag N0B38_RS02750 Protein ID WP_025912099.1
Coordinates 596694..596981 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag N0B38_RS02755 Protein ID WP_039023943.1
Coordinates 596968..597273 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0B38_RS02720 (N0B38_02720) 591707..591823 + 117 Protein_525 amino acid-binding protein -
N0B38_RS02725 (N0B38_02725) 591816..592511 + 696 WP_032664591.1 winged helix-turn-helix domain-containing protein -
N0B38_RS02730 (N0B38_02730) 592657..593127 + 471 WP_008501325.1 MarR family transcriptional regulator -
N0B38_RS02735 (N0B38_02735) 593124..594191 + 1068 WP_085930304.1 HlyD family secretion protein -
N0B38_RS02740 (N0B38_02740) 594181..595257 + 1077 WP_023293361.1 DUF2955 domain-containing protein -
N0B38_RS02745 (N0B38_02745) 595254..596525 - 1272 WP_126348752.1 DUF445 domain-containing protein -
N0B38_RS02750 (N0B38_02750) 596694..596981 + 288 WP_025912099.1 BrnT family toxin Toxin
N0B38_RS02755 (N0B38_02755) 596968..597273 + 306 WP_039023943.1 BrnA antitoxin family protein Antitoxin
N0B38_RS02760 (N0B38_02760) 597300..597938 - 639 WP_259493313.1 LysE family translocator -
N0B38_RS02765 (N0B38_02765) 597986..598729 - 744 WP_021240616.1 AraC family transcriptional regulator -
N0B38_RS02770 (N0B38_02770) 598881..600251 + 1371 WP_135345794.1 NAD-dependent succinate-semialdehyde dehydrogenase -
N0B38_RS02775 (N0B38_02775) 600297..600617 - 321 WP_008501314.1 hypothetical protein -
N0B38_RS02780 (N0B38_02780) 600617..601162 - 546 WP_008501313.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11235.68 Da        Isoelectric Point: 7.4007

>T256971 WP_025912099.1 NZ_CP104001:596694-596981 [Enterobacter roggenkampii]
MPTEYEWDSNKAKSNLQKHGIRFEDAVMVFDDPYHLSVQDRYENGEFRWQTIGLVQGLLVILVAHTVRFESGGEIIRIIS
ARKADRKERSRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11527.12 Da        Isoelectric Point: 10.0592

>AT256971 WP_039023943.1 NZ_CP104001:596968-597273 [Enterobacter roggenkampii]
MSIVKHKRGSAPEVSARREAELKALAEKPEAEIDYSDIPATDDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKNK

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ULU9

Antitoxin

Source ID Structure

References