256968

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 8933..10482 Replicon plasmid p2
Accession NZ_CP103999
Organism Ketogulonicigenium vulgare strain D3_3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NZF41_RS15485 Protein ID WP_273692222.1
Coordinates 9184..10482 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NZF41_RS15480 Protein ID WP_044008278.1
Coordinates 8933..9184 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZF41_RS15465 5222..6073 - 852 WP_273692216.1 ABC transporter permease -
NZF41_RS15470 6083..7033 - 951 WP_013385705.1 ABC transporter permease -
NZF41_RS15475 7052..8626 - 1575 WP_273692219.1 ABC transporter substrate-binding protein -
NZF41_RS15480 8933..9184 + 252 WP_044008278.1 helix-turn-helix domain-containing protein Antitoxin
NZF41_RS15485 9184..10482 + 1299 WP_273692222.1 type II toxin-antitoxin system HipA family toxin Toxin
NZF41_RS15490 10626..12452 - 1827 WP_273692224.1 response regulator -
NZF41_RS15495 12445..13320 - 876 WP_273692226.1 CheR family methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..216683 216683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-54)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 46556.39 Da        Isoelectric Point: 8.0685

>T256968 WP_273692222.1 NZ_CP103999:9184-10482 [Ketogulonicigenium vulgare]
MGRRRAYLPLDVYMNARLVGQFARQSGGAHLFTYAQSWLGWPGRLPISRALPLQGARHQGAAVIAVFDNLLPDHPQIRDR
LAARVGAGGADAFSLLAEIGRDCVGALQFLPAGEMPDAQGLQADPLSAAQIGALLSNLSAAPLGLDRTRDFRISVAGAQE
KTALLRQDDQWFAPRGATPTTHILKPAIGLLPSGVDLRNAPQNEHFCLRLPAGFGLRVADTQVADFNGVSTLVVTRFDRL
WTADGRLIRLPQEDCCQALGVPSSLKYQSDGGPGIREISALLQASDQPVQDRLDFFKANILFWLMGATDGHAKNFSLSMA
PGGRFRLAPLYDVISLQPALAAGQMQPGDMRLAMRMGASRYYRIGDITGRHILESGLDAGLSRVQILAICAEIAESAAAA
FEAASHTVQDQEMVAAIRAGFDQRLPRLMTMT

Download         Length: 1299 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9042.29 Da        Isoelectric Point: 5.6379

>AT256968 WP_044008278.1 NZ_CP103999:8933-9184 [Ketogulonicigenium vulgare]
MDHIIRSPKDIGHVLRQARKAGGLSQADLAAKAGLWQRTVSTLETGAADARLETLFDLLAALDLELQVVPRSRTDPDSFA
DLF

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References