Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1438197..1439113 Replicon chromosome
Accession NZ_CP103995
Organism Bacillus subtilis strain SRCM117109

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag N0B18_RS07710 Protein ID WP_003244695.1
Coordinates 1438367..1439113 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag N0B18_RS07705 Protein ID WP_003232646.1
Coordinates 1438197..1438367 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0B18_RS07670 (N0B18_07670) 1435056..1435385 + 330 WP_046160312.1 XkdW family protein -
N0B18_RS07675 (N0B18_07675) 1435382..1435546 + 165 WP_014479563.1 XkdX family protein -
N0B18_RS07680 (N0B18_07680) 1435593..1436432 + 840 WP_014479564.1 phage-like element PBSX protein XepA -
N0B18_RS07685 (N0B18_07685) 1436485..1436754 + 270 WP_069964126.1 hemolysin XhlA family protein -
N0B18_RS07690 (N0B18_07690) 1436767..1437030 + 264 WP_014479566.1 phage holin -
N0B18_RS07695 (N0B18_07695) 1437043..1437936 + 894 WP_021479459.1 N-acetylmuramoyl-L-alanine amidase -
N0B18_RS07700 (N0B18_07700) 1437974..1438111 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
N0B18_RS07705 (N0B18_07705) 1438197..1438367 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
N0B18_RS07710 (N0B18_07710) 1438367..1439113 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
N0B18_RS07715 (N0B18_07715) 1439223..1440224 - 1002 WP_003232642.1 inorganic phosphate transporter -
N0B18_RS07720 (N0B18_07720) 1440237..1440854 - 618 WP_003218470.1 DUF47 domain-containing protein -
N0B18_RS07725 (N0B18_07725) 1441130..1442438 - 1309 Protein_1459 serine/threonine exchanger -
N0B18_RS07730 (N0B18_07730) 1442827..1443777 + 951 WP_014479571.1 ring-cleaving dioxygenase -
N0B18_RS07735 (N0B18_07735) 1443886..1443981 + 96 Protein_1461 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1403204..1503689 100485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T256965 WP_003244695.1 NZ_CP103995:c1439113-1438367 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT256965 WP_003232646.1 NZ_CP103995:c1438367-1438197 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References