Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2344869..2345530 Replicon chromosome
Accession NZ_CP103983
Organism Cysteiniphilum sp. QT6929

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYP54_RS10225 Protein ID WP_283156418.1
Coordinates 2345111..2345530 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYP54_RS10220 Protein ID WP_283156417.1
Coordinates 2344869..2345111 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP54_RS10205 (NYP54_10210) 2342204..2342590 - 387 WP_283156415.1 type II toxin-antitoxin system VapC family toxin -
NYP54_RS10210 (NYP54_10215) 2342591..2342827 - 237 WP_151193431.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NYP54_RS10215 (NYP54_10220) 2342909..2344480 - 1572 WP_283156416.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
NYP54_RS10220 (NYP54_10225) 2344869..2345111 + 243 WP_283156417.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NYP54_RS10225 (NYP54_10230) 2345111..2345530 + 420 WP_283156418.1 type II toxin-antitoxin system VapC family toxin Toxin
NYP54_RS10230 (NYP54_10235) 2345728..2347404 - 1677 WP_283156419.1 energy-dependent translational throttle protein EttA -
NYP54_RS10235 (NYP54_10240) 2347547..2348686 - 1140 WP_283156420.1 Na+/H+ antiporter NhaA -
NYP54_RS10240 (NYP54_10245) 2348753..2349355 - 603 WP_283156421.1 TetR family transcriptional regulator -
NYP54_RS10245 (NYP54_10250) 2349446..2349715 - 270 WP_117003179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15522.19 Da        Isoelectric Point: 7.3501

>T256963 WP_283156418.1 NZ_CP103983:2345111-2345530 [Cysteiniphilum sp. QT6929]
MVNTKRYMLDTNTASYIIKGDYPALKTHLINVPMSSICISAITEAELLLGVAKKLSAKHLPMIVNEFLLRVEILPWTSQA
AKVYAKLRATCEKEGKTLSCMDMLIAAHAKAENAVLVTKDGAFYHLSKHLELEDWTNDE

Download         Length: 420 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9499.90 Da        Isoelectric Point: 8.0326

>AT256963 WP_283156417.1 NZ_CP103983:2344869-2345111 [Cysteiniphilum sp. QT6929]
MIHTAKLFMNGRSQAVRLPSSYRFDCKEVYIRRHPETGDIIISKKPGSWEDFFEMKEGKKIPKDFMADRDDEMPSQRDLF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References