Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 715602..716149 Replicon chromosome
Accession NZ_CP103983
Organism Cysteiniphilum sp. QT6929

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NYP54_RS03010 Protein ID WP_283157110.1
Coordinates 715602..715889 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NYP54_RS03015 Protein ID WP_151193220.1
Coordinates 715877..716149 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP54_RS02980 (NYP54_02980) 711087..711932 + 846 WP_283157104.1 2OG-Fe(II) oxygenase family protein -
NYP54_RS02985 (NYP54_02985) 711955..712587 + 633 WP_283157105.1 phosphatase PAP2 family protein -
NYP54_RS02990 (NYP54_02990) 712760..713455 - 696 WP_283157106.1 hypothetical protein -
NYP54_RS02995 (NYP54_02995) 713471..714088 - 618 WP_283157107.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
NYP54_RS03000 (NYP54_03000) 714097..714870 - 774 WP_283157108.1 imidazole glycerol phosphate synthase subunit HisF -
NYP54_RS03005 (NYP54_03005) 714864..715589 - 726 WP_283157109.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
NYP54_RS03010 (NYP54_03010) 715602..715889 - 288 WP_283157110.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP54_RS03015 (NYP54_03015) 715877..716149 - 273 WP_151193220.1 CopG family ribbon-helix-helix protein Antitoxin
NYP54_RS03020 (NYP54_03020) 716414..717016 - 603 WP_283157111.1 imidazole glycerol phosphate synthase subunit HisH -
NYP54_RS03025 (NYP54_03025) 717013..718083 - 1071 WP_283157112.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NYP54_RS03030 (NYP54_03030) 718070..719155 - 1086 WP_283157113.1 histidinol-phosphate transaminase -
NYP54_RS03035 (NYP54_03035) 719140..720471 - 1332 WP_283157114.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10850.44 Da        Isoelectric Point: 7.2403

>T256959 WP_283157110.1 NZ_CP103983:c715889-715602 [Cysteiniphilum sp. QT6929]
MSQIKITEGALQGIQRCQSFLESRNTLASQRAAHEIAKYIQLLKETPEIGRPLSDYLRELIIPFGDSGYAVLYRYEAMTD
ICHVLSFKHQKEAGY

Download         Length: 288 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10569.99 Da        Isoelectric Point: 6.7190

>AT256959 WP_151193220.1 NZ_CP103983:c716149-715877 [Cysteiniphilum sp. QT6929]
MSTSLKISDDLKGRIQQLARLQDRTPHWIMMRAINEYVLKEEKKEQFKQEALASWQSFQETGLHITGDEAIRWLQTWGTD
SEEPAPKCHK

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References