256952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4305345..4306159 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NZ657_RS20940 Protein ID WP_001054376.1
Coordinates 4305345..4305602 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NZ657_RS20945 Protein ID WP_001309181.1
Coordinates 4305614..4306159 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS20915 (4300633) 4300633..4301739 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NZ657_RS20920 (4301804) 4301804..4302784 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NZ657_RS20925 (4302894) 4302894..4303099 + 206 Protein_4092 HNH endonuclease -
NZ657_RS20930 (4303367) 4303367..4304607 - 1241 Protein_4093 helicase YjhR -
NZ657_RS20935 (4304723) 4304723..4304854 + 132 WP_001309182.1 hypothetical protein -
NZ657_RS20940 (4305345) 4305345..4305602 + 258 WP_001054376.1 YjhX family toxin Toxin
NZ657_RS20945 (4305614) 4305614..4306159 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NZ657_RS20950 (4306215) 4306215..4306961 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NZ657_RS20955 (4307130) 4307130..4307348 + 219 Protein_4098 hypothetical protein -
NZ657_RS20960 (4307386) 4307386..4307502 + 117 Protein_4099 VOC family protein -
NZ657_RS20965 (4307747) 4307747..4308868 + 1122 WP_000010829.1 M42 family metallopeptidase -
NZ657_RS20970 (4308865) 4308865..4309143 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NZ657_RS20975 (4309155) 4309155..4310468 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T256952 WP_001054376.1 NZ_CP103974:4305345-4305602 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT256952 WP_001309181.1 NZ_CP103974:4305614-4306159 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References