Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3673029..3673647 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NZ657_RS17950 Protein ID WP_001291435.1
Coordinates 3673429..3673647 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NZ657_RS17945 Protein ID WP_000344800.1
Coordinates 3673029..3673403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS17935 (3668118) 3668118..3669311 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NZ657_RS17940 (3669334) 3669334..3672483 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NZ657_RS17945 (3673029) 3673029..3673403 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NZ657_RS17950 (3673429) 3673429..3673647 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NZ657_RS17955 (3673819) 3673819..3674370 + 552 WP_000102564.1 maltose O-acetyltransferase -
NZ657_RS17960 (3674486) 3674486..3674956 + 471 WP_000136192.1 YlaC family protein -
NZ657_RS17965 (3675120) 3675120..3676670 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NZ657_RS17970 (3676712) 3676712..3677065 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NZ657_RS17980 (3677444) 3677444..3677755 + 312 WP_000409911.1 MGMT family protein -
NZ657_RS17985 (3677786) 3677786..3678358 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256949 WP_001291435.1 NZ_CP103974:3673429-3673647 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256949 WP_000344800.1 NZ_CP103974:3673029-3673403 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References