Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2592191..2592829 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NZ657_RS12550 Protein ID WP_000813794.1
Coordinates 2592653..2592829 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NZ657_RS12545 Protein ID WP_001270286.1
Coordinates 2592191..2592607 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS12525 (2587345) 2587345..2588286 - 942 WP_001251304.1 ABC transporter permease -
NZ657_RS12530 (2588287) 2588287..2589300 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NZ657_RS12535 (2589318) 2589318..2590461 - 1144 Protein_2456 ABC transporter substrate-binding protein -
NZ657_RS12540 (2590706) 2590706..2592112 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NZ657_RS12545 (2592191) 2592191..2592607 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NZ657_RS12550 (2592653) 2592653..2592829 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NZ657_RS12555 (2593051) 2593051..2593281 + 231 WP_000494244.1 YncJ family protein -
NZ657_RS12560 (2593373) 2593373..2595334 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NZ657_RS12565 (2595407) 2595407..2595943 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NZ657_RS12570 (2596035) 2596035..2597210 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256948 WP_000813794.1 NZ_CP103974:c2592829-2592653 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256948 WP_001270286.1 NZ_CP103974:c2592607-2592191 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References