Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2482684..2484272 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NZ657_RS12020 Protein ID WP_077487432.1
Coordinates 2482950..2484272 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NZ657_RS12015 Protein ID WP_001301023.1
Coordinates 2482684..2482950 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS12015 (2482684) 2482684..2482950 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NZ657_RS12020 (2482950) 2482950..2484272 + 1323 WP_077487432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NZ657_RS12025 (2484532) 2484532..2484894 - 363 WP_000345758.1 hypothetical protein -
NZ657_RS12030 (2484897) 2484897..2485295 - 399 WP_000981410.1 hypothetical protein -
NZ657_RS12035 (2485380) 2485380..2485832 - 453 WP_000069317.1 transcriptional regulator -
NZ657_RS12040 (2486000) 2486000..2487052 + 1053 WP_001386054.1 phage/plasmid replication protein, II/X family -
NZ657_RS12045 (2487064) 2487064..2487381 + 318 WP_000073835.1 DNA-binding protein -
NZ657_RS12050 (2487384) 2487384..2487635 + 252 WP_000381239.1 membrane protein -
NZ657_RS12055 (2487670) 2487670..2487903 + 234 WP_000473544.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49334.89 Da        Isoelectric Point: 8.5849

>T256947 WP_077487432.1 NZ_CP103974:2482950-2484272 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAREWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT256947 WP_001301023.1 NZ_CP103974:2482684-2482950 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References