Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1194841..1195682 | Replicon | chromosome |
| Accession | NZ_CP103974 | ||
| Organism | Escherichia coli strain DLI.6n | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0WJM1 |
| Locus tag | NZ657_RS05785 | Protein ID | WP_000854822.1 |
| Coordinates | 1194841..1195224 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A243ZR83 |
| Locus tag | NZ657_RS05790 | Protein ID | WP_071587515.1 |
| Coordinates | 1195314..1195682 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NZ657_RS05755 (1190332) | 1190332..1191300 | + | 969 | WP_094321578.1 | IS5 family transposase | - |
| NZ657_RS05760 (1191353) | 1191353..1192477 | - | 1125 | Protein_1127 | hypothetical protein | - |
| NZ657_RS05770 (1193211) | 1193211..1194056 | - | 846 | WP_001280435.1 | DUF4942 domain-containing protein | - |
| NZ657_RS05775 (1194153) | 1194153..1194350 | - | 198 | WP_000839263.1 | DUF957 domain-containing protein | - |
| NZ657_RS05780 (1194362) | 1194362..1194850 | - | 489 | WP_001177592.1 | DUF5983 family protein | - |
| NZ657_RS05785 (1194841) | 1194841..1195224 | - | 384 | WP_000854822.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| NZ657_RS05790 (1195314) | 1195314..1195682 | - | 369 | WP_071587515.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NZ657_RS05795 (1195762) | 1195762..1195983 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| NZ657_RS05800 (1196052) | 1196052..1196528 | - | 477 | WP_072645454.1 | RadC family protein | - |
| NZ657_RS05805 (1196543) | 1196543..1197028 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| NZ657_RS05810 (1197119) | 1197119..1197937 | - | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1190377..1191300 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14295.32 Da Isoelectric Point: 8.2830
>T256940 WP_000854822.1 NZ_CP103974:c1195224-1194841 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
Download Length: 384 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13631.41 Da Isoelectric Point: 6.6244
>AT256940 WP_071587515.1 NZ_CP103974:c1195682-1195314 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0WJM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A243ZR83 |