Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4057450..4058068 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NZD79_RS19805 Protein ID WP_001291435.1
Coordinates 4057450..4057668 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NZD79_RS19810 Protein ID WP_000344800.1
Coordinates 4057694..4058068 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS19770 (4052739) 4052739..4053311 + 573 WP_000779831.1 YbaY family lipoprotein -
NZD79_RS19775 (4053342) 4053342..4053653 - 312 WP_000409911.1 MGMT family protein -
NZD79_RS19785 (4054032) 4054032..4054385 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NZD79_RS19790 (4054427) 4054427..4055977 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NZD79_RS19795 (4056141) 4056141..4056611 - 471 WP_000136192.1 YlaC family protein -
NZD79_RS19800 (4056727) 4056727..4057278 - 552 WP_000102564.1 maltose O-acetyltransferase -
NZD79_RS19805 (4057450) 4057450..4057668 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NZD79_RS19810 (4057694) 4057694..4058068 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NZD79_RS19815 (4058614) 4058614..4061763 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NZD79_RS19820 (4061786) 4061786..4062979 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256934 WP_001291435.1 NZ_CP103972:c4057668-4057450 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256934 WP_000344800.1 NZ_CP103972:c4058068-4057694 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References