Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1781123..1781777 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NZD79_RS08610 Protein ID WP_000244777.1
Coordinates 1781123..1781530 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag NZD79_RS08615 Protein ID WP_029487477.1
Coordinates 1781511..1781777 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS08590 (1777080) 1777080..1778813 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
NZD79_RS08595 (1778819) 1778819..1779529 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NZD79_RS08600 (1779554) 1779554..1780450 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NZD79_RS08605 (1780562) 1780562..1781083 + 522 WP_001055874.1 flavodoxin FldB -
NZD79_RS08610 (1781123) 1781123..1781530 - 408 WP_000244777.1 protein YgfX Toxin
NZD79_RS08615 (1781511) 1781511..1781777 - 267 WP_029487477.1 FAD assembly factor SdhE Antitoxin
NZD79_RS08620 (1782020) 1782020..1783000 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NZD79_RS08625 (1783196) 1783196..1783855 - 660 WP_000250274.1 hemolysin III family protein -
NZD79_RS08630 (1784019) 1784019..1784330 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NZD79_RS08635 (1784375) 1784375..1785808 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NZD79_RS08640 (1785865) 1785865..1786608 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T256926 WP_000244777.1 NZ_CP103972:c1781530-1781123 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10537.08 Da        Isoelectric Point: 5.1599

>AT256926 WP_029487477.1 NZ_CP103972:c1781777-1781511 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGSVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure

References