Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2455451..2456701 Replicon chromosome
Accession NZ_CP103965
Organism Pseudomonas sp. N3-W

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYP20_RS11405 Protein ID WP_259502337.1
Coordinates 2455451..2456026 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYP20_RS11410 Protein ID WP_259502339.1
Coordinates 2456144..2456701 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP20_RS11380 (NYP20_11380) 2450527..2450796 + 270 WP_259502328.1 hypothetical protein -
NYP20_RS11385 (NYP20_11385) 2450953..2452074 + 1122 WP_259502330.1 DUF2971 domain-containing protein -
NYP20_RS11390 (NYP20_11390) 2452468..2453127 + 660 WP_259502332.1 hypothetical protein -
NYP20_RS11395 (NYP20_11395) 2453344..2454096 - 753 WP_259502334.1 SDR family oxidoreductase -
NYP20_RS11400 (NYP20_11400) 2454213..2455136 + 924 WP_259502336.1 LysR family transcriptional regulator -
NYP20_RS11405 (NYP20_11405) 2455451..2456026 - 576 WP_259502337.1 HD domain-containing protein Toxin
NYP20_RS11410 (NYP20_11410) 2456144..2456701 - 558 WP_259502339.1 helix-turn-helix transcriptional regulator Antitoxin
NYP20_RS11415 (NYP20_11415) 2457000..2457491 - 492 WP_259502341.1 hypothetical protein -
NYP20_RS11420 (NYP20_11420) 2457668..2458630 - 963 WP_259502343.1 Rap1a/Tai family immunity protein -
NYP20_RS11425 (NYP20_11425) 2458760..2459590 - 831 WP_259502347.1 hypothetical protein -
NYP20_RS11430 (NYP20_11430) 2459871..2460104 - 234 Protein_2244 transposase domain-containing protein -
NYP20_RS11435 (NYP20_11435) 2460796..2461590 + 795 WP_259502349.1 nitrilase-related carbon-nitrogen hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2441329..2461590 20261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-63)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21704.86 Da        Isoelectric Point: 5.0047

>T256915 WP_259502337.1 NZ_CP103965:c2456026-2455451 [Pseudomonas sp. N3-W]
MDIEKIKGRLEFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAIVFGDYLTGLDRLKMLKMCVIHDLGEAISGDIP
AVNKDLFPNKSERERSDLVLLTKALDEPLKTEILALWDDYENALSPEAVAVKALDKLETMLQHNQGKNPPDFDYEFNLAY
GKKYTDAAPLFEALRNIIDQDTKEHMLANPK

Download         Length: 576 bp

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20839.04 Da        Isoelectric Point: 9.2953

>AT256915 WP_259502339.1 NZ_CP103965:c2456701-2456144 [Pseudomonas sp. N3-W]
MSEMLLNPELPGVMLRRWRQLHRVKQSHAAELFSVTQSTISRWESGLLELDTLAYKKLEKLLNARLDAAADQALARLVRE
SSRPVHLICDLTHRLLASSPSRAAQFASPINELLGRSLWRFATPEIIGKEFALNESGWREVFAPPALEFRTGNNDSLLVP
ISQSLCRWTRIPLSDGTAARLVETL

Download         Length: 558 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References