Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 272028..272671 Replicon chromosome
Accession NZ_CP103965
Organism Pseudomonas sp. N3-W

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NYP20_RS01205 Protein ID WP_259498221.1
Coordinates 272028..272210 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NYP20_RS01210 Protein ID WP_259503073.1
Coordinates 272270..272671 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP20_RS01190 (NYP20_01190) 267982..268908 + 927 WP_259498217.1 serine acetyltransferase -
NYP20_RS01195 (NYP20_01195) 269318..271279 + 1962 WP_259503072.1 choline transporter BetT -
NYP20_RS01200 (NYP20_01200) 271294..271551 - 258 WP_259498219.1 hypothetical protein -
NYP20_RS01205 (NYP20_01205) 272028..272210 + 183 WP_259498221.1 type II toxin-antitoxin system HicA family toxin Toxin
NYP20_RS01210 (NYP20_01210) 272270..272671 + 402 WP_259503073.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NYP20_RS01215 (NYP20_01215) 272813..273853 - 1041 WP_259498223.1 LacI family DNA-binding transcriptional regulator -
NYP20_RS01220 (NYP20_01220) 274060..276285 + 2226 WP_259498225.1 TonB-dependent receptor -
NYP20_RS01225 (NYP20_01225) 276288..277607 + 1320 WP_259498227.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6785.87 Da        Isoelectric Point: 10.7495

>T256911 WP_259498221.1 NZ_CP103965:272028-272210 [Pseudomonas sp. N3-W]
MRSREMIRMIEHDGSYLVAVKGSHHQYKHSFKSGRVTIKHPDSDLPKGTINGILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14541.31 Da        Isoelectric Point: 4.3752

>AT256911 WP_259503073.1 NZ_CP103965:272270-272671 [Pseudomonas sp. N3-W]
MKFPVVLHKDADSEYGVIIPDVPGCFSAGATVSQAFESVKEALALHYEGLVADGDPLPQVQEIDAHLDNPDYAGGVWGVV
EFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References