256908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1721604..1722392 Replicon chromosome
Accession NZ_CP103964
Organism Staphylococcus hyicus strain MM2101

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NZD48_RS08355 Protein ID WP_259488809.1
Coordinates 1721937..1722392 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag NZD48_RS08350 Protein ID WP_259488808.1
Coordinates 1721604..1721924 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD48_RS08300 (NZD48_08300) 1716822..1717361 - 540 WP_259488799.1 hypothetical protein -
NZD48_RS08305 (NZD48_08305) 1717368..1718705 - 1338 WP_259488800.1 DEAD/DEAH box helicase -
NZD48_RS08310 (NZD48_08310) 1718689..1719399 - 711 WP_259488801.1 AAA family ATPase -
NZD48_RS08315 (NZD48_08315) 1719399..1719884 - 486 WP_259488802.1 siphovirus Gp157 family protein -
NZD48_RS08320 (NZD48_08320) 1719877..1720053 - 177 WP_259488803.1 hypothetical protein -
NZD48_RS08325 (NZD48_08325) 1720131..1720298 - 168 WP_259488804.1 hypothetical protein -
NZD48_RS08330 (NZD48_08330) 1720292..1720504 - 213 WP_107396783.1 hypothetical protein -
NZD48_RS08335 (NZD48_08335) 1720602..1720880 + 279 WP_259488806.1 hypothetical protein -
NZD48_RS08340 (NZD48_08340) 1720861..1721025 - 165 WP_259488807.1 hypothetical protein -
NZD48_RS08345 (NZD48_08345) 1721185..1721382 - 198 WP_105967178.1 helix-turn-helix transcriptional regulator -
NZD48_RS08350 (NZD48_08350) 1721604..1721924 + 321 WP_259488808.1 helix-turn-helix transcriptional regulator Antitoxin
NZD48_RS08355 (NZD48_08355) 1721937..1722392 + 456 WP_259488809.1 ImmA/IrrE family metallo-endopeptidase Toxin
NZD48_RS08360 (NZD48_08360) 1722450..1722745 + 296 Protein_1614 TM2 domain-containing protein -
NZD48_RS08365 (NZD48_08365) 1722901..1723383 + 483 WP_065520445.1 hypothetical protein -
NZD48_RS08370 (NZD48_08370) 1723383..1723727 + 345 WP_065520444.1 DUF3969 family protein -
NZD48_RS08375 (NZD48_08375) 1724061..1724534 + 474 WP_257052661.1 hypothetical protein -
NZD48_RS08380 (NZD48_08380) 1724539..1725330 + 792 WP_257052660.1 DUF1828 domain-containing protein -
NZD48_RS08385 (NZD48_08385) 1725386..1726411 + 1026 WP_259488812.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1686922..1746080 59158
- inside Prophage - - 1686922..1780453 93531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(23-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-65)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 17698.30 Da        Isoelectric Point: 7.4546

>T256908 WP_259488809.1 NZ_CP103964:1721937-1722392 [Staphylococcus hyicus]
MAKYEDLMIQNSHIPISDEYSLKRNFKGIYANGVILIDKNLSNAEKHEVLSEELAHHKLTYGNILDQSNMLNRKFELKAR
RLANESVITLQGLINAFNYGVQNIYDLATYFEVTKDFVLDAIQHYKQKYGLRTRYGKYIIEFEPLIIYKDL

Download         Length: 456 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12247.75 Da        Isoelectric Point: 5.6631

>AT256908 WP_259488808.1 NZ_CP103964:1721604-1721924 [Staphylococcus hyicus]
MRNNDEIISLVAKIMEQNNLSTSELARRLNIAKSSVSRYLNRTSQFPLNKVNDFAHALNVTPEYLLGVEENKQNTLAAHL
DGDFTEEELQEILEYAEFVKQKHRNK

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References