256906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 866829..867353 Replicon chromosome
Accession NZ_CP103964
Organism Staphylococcus hyicus strain MM2101

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag NZD48_RS04075 Protein ID WP_037567539.1
Coordinates 867000..867353 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0A8HN67
Locus tag NZD48_RS04070 Protein ID WP_039644674.1
Coordinates 866829..866999 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD48_RS04045 (NZD48_04045) 862624..863100 + 477 WP_252538113.1 PH domain-containing protein -
NZD48_RS04050 (NZD48_04050) 863093..864583 + 1491 WP_259490166.1 PH domain-containing protein -
NZD48_RS04055 (NZD48_04055) 864564..865079 + 516 WP_259490167.1 PH domain-containing protein -
NZD48_RS04060 (NZD48_04060) 865147..865497 + 351 WP_259490169.1 holo-ACP synthase -
NZD48_RS04065 (NZD48_04065) 865597..866745 + 1149 WP_259490171.1 alanine racemase -
NZD48_RS04070 (NZD48_04070) 866829..866999 + 171 WP_039644674.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NZD48_RS04075 (NZD48_04075) 867000..867353 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NZD48_RS04080 (NZD48_04080) 867430..868416 + 987 WP_241961404.1 PP2C family protein-serine/threonine phosphatase -
NZD48_RS04085 (NZD48_04085) 868497..868823 + 327 WP_039644676.1 anti-sigma factor antagonist -
NZD48_RS04090 (NZD48_04090) 868826..869305 + 480 WP_039644678.1 anti-sigma B factor RsbW -
NZD48_RS04095 (NZD48_04095) 869280..870050 + 771 WP_107633600.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T256906 WP_037567539.1 NZ_CP103964:867000-867353 [Staphylococcus hyicus]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT256906 WP_039644674.1 NZ_CP103964:866829-866999 [Staphylococcus hyicus]
MSAFYQTRGKSLEQLLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSNNKDD

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8HN67

References