256903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 960316..960875 Replicon chromosome
Accession NZ_CP103958
Organism Brucella sp. 1315

Toxin (Protein)


Gene name brnT Uniprot ID D6LP74
Locus tag NYO63_RS04750 Protein ID WP_004688321.1
Coordinates 960630..960875 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag NYO63_RS04745 Protein ID WP_002964097.1
Coordinates 960316..960630 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO63_RS04695 (NYO63_04695) 955876..956901 - 1026 WP_259598411.1 site-specific integrase -
NYO63_RS04700 (NYO63_04700) 956888..957088 - 201 WP_259598412.1 hypothetical protein -
NYO63_RS04705 (NYO63_04705) 957091..957306 - 216 WP_002971459.1 hypothetical protein -
NYO63_RS04710 (NYO63_04710) 957303..957506 - 204 WP_002964088.1 hypothetical protein -
NYO63_RS04715 (NYO63_04715) 957421..957642 + 222 Protein_923 hypothetical protein -
NYO63_RS04720 (NYO63_04720) 957668..958255 + 588 WP_259598413.1 hypothetical protein -
NYO63_RS04725 (NYO63_04725) 958490..959200 + 711 WP_259598414.1 porin family protein -
NYO63_RS04735 (NYO63_04735) 959798..959968 - 171 WP_002964095.1 DUF1508 domain-containing protein -
NYO63_RS04740 (NYO63_04740) 959967..960200 + 234 WP_259598415.1 hypothetical protein -
NYO63_RS04745 (NYO63_04745) 960316..960630 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
NYO63_RS04750 (NYO63_04750) 960630..960875 - 246 WP_004688321.1 BrnT family toxin Toxin
NYO63_RS04755 (NYO63_04755) 960962..961291 + 330 WP_259598416.1 twin-arginine translocation signal domain-containing protein -
NYO63_RS04765 (NYO63_04765) 962280..963050 + 771 Protein_932 phage portal protein -
NYO63_RS04770 (NYO63_04770) 963188..965092 + 1905 WP_259598419.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - wboA / wbdA 955876..968151 12275
- flank IS/Tn - - 961564..962223 659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9172.86 Da        Isoelectric Point: 10.3158

>T256903 WP_004688321.1 NZ_CP103958:c960875-960630 [Brucella sp. 1315]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRPASQKERK
L

Download         Length: 246 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT256903 WP_002964097.1 NZ_CP103958:c960630-960316 [Brucella sp. 1315]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References