Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 377144..378174 Replicon chromosome
Accession NZ_CP103903
Organism Corynebacterium diphtheriae bv. gravis strain 6211/17

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY027_RS01765 Protein ID WP_259596860.1
Coordinates 377144..377563 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY027_RS01770 Protein ID WP_010934564.1
Coordinates 377608..378174 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY027_RS01750 (NY027_01750) 373801..374655 + 855 WP_010934561.1 hypothetical protein -
NY027_RS01755 (NY027_01755) 374648..375556 - 909 WP_010934562.1 DUF1906 domain-containing protein -
NY027_RS01760 (NY027_01760) 375685..376884 - 1200 WP_010934563.1 cation:proton antiporter -
NY027_RS01765 (NY027_01765) 377144..377563 - 420 WP_259596860.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY027_RS01770 (NY027_01770) 377608..378174 - 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY027_RS01775 (NY027_01775) 378495..378767 - 273 WP_010934566.1 hypothetical protein -
NY027_RS01780 (NY027_01780) 379927..380367 - 441 WP_014301588.1 hypothetical protein -
NY027_RS01785 (NY027_01785) 380455..380727 + 273 WP_226813719.1 hypothetical protein -
NY027_RS01790 (NY027_01790) 380750..381172 - 423 WP_241800074.1 DUF4065 domain-containing protein -
NY027_RS01795 (NY027_01795) 381462..381785 - 324 WP_010934571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 377144..396707 19563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(34-116)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15564.73 Da        Isoelectric Point: 8.7021

>T256902 WP_259596860.1 NZ_CP103903:c377563-377144 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGSIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256902 WP_010934564.1 NZ_CP103903:c378174-377608 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References