Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 378293..379323 | Replicon | chromosome |
| Accession | NZ_CP103902 | ||
| Organism | Corynebacterium diphtheriae bv. mitis strain 6272/17 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | NY028_RS01960 | Protein ID | WP_070794874.1 |
| Coordinates | 378904..379323 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | NY028_RS01955 | Protein ID | WP_196970579.1 |
| Coordinates | 378293..378859 (+) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NY028_RS01920 (NY028_01920) | 373740..374117 | - | 378 | WP_196970585.1 | hypothetical protein | - |
| NY028_RS01925 (NY028_01925) | 374172..374438 | - | 267 | WP_196970584.1 | hypothetical protein | - |
| NY028_RS01930 (NY028_01930) | 374580..375107 | + | 528 | WP_196970583.1 | helix-turn-helix transcriptional regulator | - |
| NY028_RS01935 (NY028_01935) | 375082..375483 | + | 402 | WP_196970582.1 | ImmA/IrrE family metallo-endopeptidase | - |
| NY028_RS01940 (NY028_01940) | 375612..375983 | + | 372 | WP_196970581.1 | hypothetical protein | - |
| NY028_RS01945 (NY028_01945) | 376120..377250 | + | 1131 | WP_196970580.1 | tyrosine-type recombinase/integrase | - |
| NY028_RS01950 (NY028_01950) | 377685..377960 | - | 276 | WP_014309249.1 | hypothetical protein | - |
| NY028_RS01955 (NY028_01955) | 378293..378859 | + | 567 | WP_196970579.1 | Panacea domain-containing protein | Antitoxin |
| NY028_RS01960 (NY028_01960) | 378904..379323 | + | 420 | WP_070794874.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| NY028_RS01965 (NY028_01965) | 379583..380782 | + | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| NY028_RS01970 (NY028_01970) | 380911..381819 | + | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| NY028_RS01975 (NY028_01975) | 381812..382666 | - | 855 | WP_010934561.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 330596..379323 | 48727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15477.61 Da Isoelectric Point: 8.2756
>T256900 WP_070794874.1 NZ_CP103902:378904-379323 [Corynebacterium diphtheriae bv. mitis]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
Antitoxin
Download Length: 189 a.a. Molecular weight: 20992.47 Da Isoelectric Point: 4.6309
>AT256900 WP_196970579.1 NZ_CP103902:378293-378859 [Corynebacterium diphtheriae bv. mitis]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|