Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 2400176..2401206 Replicon chromosome
Accession NZ_CP103900
Organism Corynebacterium diphtheriae bv. gravis strain 7072/17

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY030_RS11285 Protein ID WP_199323424.1
Coordinates 2400787..2401206 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY030_RS11280 Protein ID WP_010934564.1
Coordinates 2400176..2400742 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY030_RS11255 (NY030_11255) 2396567..2396890 + 324 WP_010934571.1 hypothetical protein -
NY030_RS11260 (NY030_11260) 2397282..2397650 + 369 WP_244658603.1 hypothetical protein -
NY030_RS11265 (NY030_11265) 2397623..2397895 - 273 WP_226813719.1 hypothetical protein -
NY030_RS11270 (NY030_11270) 2397983..2398423 + 441 WP_014301588.1 hypothetical protein -
NY030_RS11275 (NY030_11275) 2399583..2399855 + 273 WP_010934566.1 hypothetical protein -
NY030_RS11280 (NY030_11280) 2400176..2400742 + 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY030_RS11285 (NY030_11285) 2400787..2401206 + 420 WP_199323424.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY030_RS11290 (NY030_11290) 2401466..2402665 + 1200 WP_010934563.1 cation:proton antiporter -
NY030_RS11295 (NY030_11295) 2402794..2403702 + 909 WP_010934562.1 DUF1906 domain-containing protein -
NY030_RS11300 (NY030_11300) 2403695..2404549 - 855 WP_010934561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2382427..2402665 20238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(10-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15548.73 Da        Isoelectric Point: 8.7021

>T256898 WP_199323424.1 NZ_CP103900:2400787-2401206 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256898 WP_010934564.1 NZ_CP103900:2400176-2400742 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References