Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 2387338..2388368 Replicon chromosome
Accession NZ_CP103897
Organism Corynebacterium diphtheriae bv. gravis strain 2736/18

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY033_RS11140 Protein ID WP_199323424.1
Coordinates 2387949..2388368 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY033_RS11135 Protein ID WP_010934564.1
Coordinates 2387338..2387904 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY033_RS11110 (NY033_11110) 2383727..2384050 + 324 WP_010934571.1 hypothetical protein -
NY033_RS11115 (NY033_11115) 2384319..2384762 + 444 WP_259564882.1 DUF4065 domain-containing protein -
NY033_RS11120 (NY033_11120) 2384785..2385057 - 273 WP_226813719.1 hypothetical protein -
NY033_RS11125 (NY033_11125) 2385145..2385585 + 441 WP_014301588.1 hypothetical protein -
NY033_RS11130 (NY033_11130) 2386745..2387017 + 273 WP_010934566.1 hypothetical protein -
NY033_RS11135 (NY033_11135) 2387338..2387904 + 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY033_RS11140 (NY033_11140) 2387949..2388368 + 420 WP_199323424.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY033_RS11145 (NY033_11145) 2388628..2389827 + 1200 WP_010934563.1 cation:proton antiporter -
NY033_RS11150 (NY033_11150) 2389956..2390864 + 909 WP_010934562.1 DUF1906 domain-containing protein -
NY033_RS11155 (NY033_11155) 2390857..2391711 - 855 WP_010934561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2368805..2389827 21022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(10-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15548.73 Da        Isoelectric Point: 8.7021

>T256895 WP_199323424.1 NZ_CP103897:2387949-2388368 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256895 WP_010934564.1 NZ_CP103897:2387338-2387904 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References