Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 739484..740514 | Replicon | chromosome |
| Accession | NZ_CP103896 | ||
| Organism | Corynebacterium diphtheriae bv. gravis strain 4674/18 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | NY034_RS03600 | Protein ID | WP_199323424.1 |
| Coordinates | 739484..739903 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | Q6NIH9 |
| Locus tag | NY034_RS03605 | Protein ID | WP_010934564.1 |
| Coordinates | 739948..740514 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NY034_RS03585 (NY034_03585) | 736141..736995 | + | 855 | WP_010934561.1 | hypothetical protein | - |
| NY034_RS03590 (NY034_03590) | 736988..737896 | - | 909 | WP_010934562.1 | DUF1906 domain-containing protein | - |
| NY034_RS03595 (NY034_03595) | 738025..739224 | - | 1200 | WP_010934563.1 | cation:proton antiporter | - |
| NY034_RS03600 (NY034_03600) | 739484..739903 | - | 420 | WP_199323424.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| NY034_RS03605 (NY034_03605) | 739948..740514 | - | 567 | WP_010934564.1 | Panacea domain-containing protein | Antitoxin |
| NY034_RS03610 (NY034_03610) | 740835..741107 | - | 273 | WP_010934566.1 | hypothetical protein | - |
| NY034_RS03615 (NY034_03615) | 742267..742707 | - | 441 | WP_014301588.1 | hypothetical protein | - |
| NY034_RS03620 (NY034_03620) | 742795..743067 | + | 273 | WP_226813719.1 | hypothetical protein | - |
| NY034_RS03625 (NY034_03625) | 743040..743408 | - | 369 | WP_244658603.1 | hypothetical protein | - |
| NY034_RS03630 (NY034_03630) | 743800..744123 | - | 324 | WP_010934571.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 739484..759045 | 19561 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15548.73 Da Isoelectric Point: 8.7021
>T256894 WP_199323424.1 NZ_CP103896:c739903-739484 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
Antitoxin
Download Length: 189 a.a. Molecular weight: 21022.71 Da Isoelectric Point: 4.6246
>AT256894 WP_010934564.1 NZ_CP103896:c740514-739948 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|