Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 377063..378093 Replicon chromosome
Accession NZ_CP103893
Organism Corynebacterium diphtheriae bv. gravis strain 5379/19

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY037_RS01765 Protein ID WP_199323424.1
Coordinates 377063..377482 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY037_RS01770 Protein ID WP_010934564.1
Coordinates 377527..378093 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY037_RS01750 (NY037_01750) 373720..374574 + 855 WP_010934561.1 hypothetical protein -
NY037_RS01755 (NY037_01755) 374567..375475 - 909 WP_010934562.1 DUF1906 domain-containing protein -
NY037_RS01760 (NY037_01760) 375604..376803 - 1200 WP_010934563.1 cation:proton antiporter -
NY037_RS01765 (NY037_01765) 377063..377482 - 420 WP_199323424.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY037_RS01770 (NY037_01770) 377527..378093 - 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY037_RS01775 (NY037_01775) 378414..378686 - 273 WP_010934566.1 hypothetical protein -
NY037_RS01780 (NY037_01780) 379846..380286 - 441 WP_014301588.1 hypothetical protein -
NY037_RS01785 (NY037_01785) 380374..380646 + 273 WP_226813719.1 hypothetical protein -
NY037_RS01790 (NY037_01790) 380619..380987 - 369 WP_244658603.1 hypothetical protein -
NY037_RS01795 (NY037_01795) 381379..381702 - 324 WP_010934571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 377063..396624 19561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(10-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15548.73 Da        Isoelectric Point: 8.7021

>T256889 WP_199323424.1 NZ_CP103893:c377482-377063 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256889 WP_010934564.1 NZ_CP103893:c378093-377527 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References