Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 742016..743046 | Replicon | chromosome |
| Accession | NZ_CP103891 | ||
| Organism | Corynebacterium diphtheriae bv. mitis strain 824/20 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | NY039_RS03675 | Protein ID | WP_070794874.1 |
| Coordinates | 742016..742435 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | NY039_RS03680 | Protein ID | WP_196970579.1 |
| Coordinates | 742480..743046 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NY039_RS03660 (NY039_03660) | 738673..739527 | + | 855 | WP_010934561.1 | hypothetical protein | - |
| NY039_RS03665 (NY039_03665) | 739520..740428 | - | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| NY039_RS03670 (NY039_03670) | 740557..741756 | - | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| NY039_RS03675 (NY039_03675) | 742016..742435 | - | 420 | WP_070794874.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| NY039_RS03680 (NY039_03680) | 742480..743046 | - | 567 | WP_196970579.1 | Panacea domain-containing protein | Antitoxin |
| NY039_RS03685 (NY039_03685) | 743379..743654 | + | 276 | WP_014309249.1 | hypothetical protein | - |
| NY039_RS03690 (NY039_03690) | 744089..745219 | - | 1131 | WP_196970580.1 | tyrosine-type recombinase/integrase | - |
| NY039_RS03695 (NY039_03695) | 745356..745727 | - | 372 | WP_196970581.1 | hypothetical protein | - |
| NY039_RS03700 (NY039_03700) | 745856..746257 | - | 402 | WP_196970582.1 | ImmA/IrrE family metallo-endopeptidase | - |
| NY039_RS03705 (NY039_03705) | 746232..746759 | - | 528 | WP_196970583.1 | helix-turn-helix transcriptional regulator | - |
| NY039_RS03710 (NY039_03710) | 746901..747167 | + | 267 | WP_196970584.1 | hypothetical protein | - |
| NY039_RS03715 (NY039_03715) | 747222..747599 | + | 378 | WP_196970585.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 742016..790743 | 48727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15477.61 Da Isoelectric Point: 8.2756
>T256887 WP_070794874.1 NZ_CP103891:c742435-742016 [Corynebacterium diphtheriae bv. mitis]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
Antitoxin
Download Length: 189 a.a. Molecular weight: 20992.47 Da Isoelectric Point: 4.6309
>AT256887 WP_196970579.1 NZ_CP103891:c743046-742480 [Corynebacterium diphtheriae bv. mitis]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|