Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 378307..379337 | Replicon | chromosome |
| Accession | NZ_CP103890 | ||
| Organism | Corynebacterium diphtheriae bv. mitis strain 38009/20 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | NY040_RS01955 | Protein ID | WP_070794874.1 |
| Coordinates | 378918..379337 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | NY040_RS01950 | Protein ID | WP_196970579.1 |
| Coordinates | 378307..378873 (+) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NY040_RS01915 (NY040_01915) | 373754..374131 | - | 378 | WP_196970585.1 | hypothetical protein | - |
| NY040_RS01920 (NY040_01920) | 374186..374452 | - | 267 | WP_196970584.1 | hypothetical protein | - |
| NY040_RS01925 (NY040_01925) | 374594..375121 | + | 528 | WP_196970583.1 | helix-turn-helix transcriptional regulator | - |
| NY040_RS01930 (NY040_01930) | 375096..375497 | + | 402 | WP_196970582.1 | ImmA/IrrE family metallo-endopeptidase | - |
| NY040_RS01935 (NY040_01935) | 375626..375997 | + | 372 | WP_196970581.1 | hypothetical protein | - |
| NY040_RS01940 (NY040_01940) | 376134..377264 | + | 1131 | WP_196970580.1 | tyrosine-type recombinase/integrase | - |
| NY040_RS01945 (NY040_01945) | 377699..377974 | - | 276 | WP_014309249.1 | hypothetical protein | - |
| NY040_RS01950 (NY040_01950) | 378307..378873 | + | 567 | WP_196970579.1 | Panacea domain-containing protein | Antitoxin |
| NY040_RS01955 (NY040_01955) | 378918..379337 | + | 420 | WP_070794874.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| NY040_RS01960 (NY040_01960) | 379597..380796 | + | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| NY040_RS01965 (NY040_01965) | 380925..381833 | + | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| NY040_RS01970 (NY040_01970) | 381826..382680 | - | 855 | WP_010934561.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 330610..379337 | 48727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15477.61 Da Isoelectric Point: 8.2756
>T256884 WP_070794874.1 NZ_CP103890:378918-379337 [Corynebacterium diphtheriae bv. mitis]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
Antitoxin
Download Length: 189 a.a. Molecular weight: 20992.47 Da Isoelectric Point: 4.6309
>AT256884 WP_196970579.1 NZ_CP103890:378307-378873 [Corynebacterium diphtheriae bv. mitis]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|