Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 2401431..2402461 Replicon chromosome
Accession NZ_CP103889
Organism Corynebacterium diphtheriae bv. gravis strain 49390/20

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY041_RS11280 Protein ID WP_199323424.1
Coordinates 2402042..2402461 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY041_RS11275 Protein ID WP_010934564.1
Coordinates 2401431..2401997 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY041_RS11255 (NY041_11255) 2397821..2398144 + 324 WP_010934571.1 hypothetical protein -
NY041_RS11260 (NY041_11260) 2398434..2399021 + 588 WP_241805130.1 DUF4065 domain-containing protein -
NY041_RS11265 (NY041_11265) 2399238..2399678 + 441 WP_014301588.1 hypothetical protein -
NY041_RS11270 (NY041_11270) 2400838..2401110 + 273 WP_010934566.1 hypothetical protein -
NY041_RS11275 (NY041_11275) 2401431..2401997 + 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY041_RS11280 (NY041_11280) 2402042..2402461 + 420 WP_199323424.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY041_RS11285 (NY041_11285) 2402721..2403920 + 1200 WP_010934563.1 cation:proton antiporter -
NY041_RS11290 (NY041_11290) 2404049..2404957 + 909 WP_010934562.1 DUF1906 domain-containing protein -
NY041_RS11295 (NY041_11295) 2404950..2405804 - 855 WP_010934561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2382900..2403920 21020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(10-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15548.73 Da        Isoelectric Point: 8.7021

>T256883 WP_199323424.1 NZ_CP103889:2402042-2402461 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256883 WP_010934564.1 NZ_CP103889:2401431-2401997 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References