Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 739458..740488 Replicon chromosome
Accession NZ_CP103888
Organism Corynebacterium diphtheriae bv. gravis strain 14225/20

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NY042_RS03590 Protein ID WP_199323424.1
Coordinates 739458..739877 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q6NIH9
Locus tag NY042_RS03595 Protein ID WP_010934564.1
Coordinates 739922..740488 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY042_RS03575 (NY042_03575) 736115..736969 + 855 WP_010934561.1 hypothetical protein -
NY042_RS03580 (NY042_03580) 736962..737870 - 909 WP_010934562.1 DUF1906 domain-containing protein -
NY042_RS03585 (NY042_03585) 737999..739198 - 1200 WP_010934563.1 cation:proton antiporter -
NY042_RS03590 (NY042_03590) 739458..739877 - 420 WP_199323424.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NY042_RS03595 (NY042_03595) 739922..740488 - 567 WP_010934564.1 Panacea domain-containing protein Antitoxin
NY042_RS03600 (NY042_03600) 740809..741081 - 273 WP_010934566.1 hypothetical protein -
NY042_RS03605 (NY042_03605) 742241..742681 - 441 WP_014301588.1 hypothetical protein -
NY042_RS03610 (NY042_03610) 742769..743041 + 273 WP_226813719.1 hypothetical protein -
NY042_RS03615 (NY042_03615) 743014..743382 - 369 WP_244658603.1 hypothetical protein -
NY042_RS03620 (NY042_03620) 743774..744097 - 324 WP_010934571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 739458..759018 19560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(10-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15548.73 Da        Isoelectric Point: 8.7021

>T256882 WP_199323424.1 NZ_CP103888:c739877-739458 [Corynebacterium diphtheriae bv. gravis]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21022.71 Da        Isoelectric Point: 4.6246

>AT256882 WP_010934564.1 NZ_CP103888:c740488-739922 [Corynebacterium diphtheriae bv. gravis]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1BUC0

References