Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3826793..3827397 Replicon chromosome
Accession NZ_CP103872
Organism Herbaspirillum huttiense strain ZXN111

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NY669_RS17100 Protein ID WP_259432730.1
Coordinates 3826793..3826975 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NY669_RS17105 Protein ID WP_259432731.1
Coordinates 3826993..3827397 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY669_RS17080 (NY669_17080) 3822924..3823415 + 492 WP_259432726.1 response regulator -
NY669_RS17085 (NY669_17085) 3823495..3823743 - 249 WP_259432727.1 hypothetical protein -
NY669_RS17090 (NY669_17090) 3824085..3825008 + 924 WP_259432728.1 diguanylate cyclase -
NY669_RS17095 (NY669_17095) 3825484..3826095 - 612 WP_259432729.1 hypothetical protein -
NY669_RS17100 (NY669_17100) 3826793..3826975 + 183 WP_259432730.1 type II toxin-antitoxin system HicA family toxin Toxin
NY669_RS17105 (NY669_17105) 3826993..3827397 + 405 WP_259432731.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NY669_RS17110 (NY669_17110) 3827404..3827805 - 402 Protein_3376 capsid portal protein -
NY669_RS17115 (NY669_17115) 3827840..3828100 + 261 WP_259432732.1 tyrosine-type recombinase/integrase -
NY669_RS17125 (NY669_17125) 3828491..3829057 + 567 WP_034341204.1 NUDIX hydrolase -
NY669_RS17130 (NY669_17130) 3829075..3829818 + 744 WP_121044821.1 leucyl/phenylalanyl-tRNA--protein transferase -
NY669_RS17135 (NY669_17135) 3829938..3830666 + 729 WP_034341208.1 arginyltransferase -
NY669_RS17140 (NY669_17140) 3830818..3831885 + 1068 WP_259432733.1 quinone-dependent dihydroorotate dehydrogenase -
NY669_RS17145 (NY669_17145) 3831957..3832100 - 144 WP_157845704.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6701.85 Da        Isoelectric Point: 11.0850

>T256879 WP_259432730.1 NZ_CP103872:3826793-3826975 [Herbaspirillum huttiense]
MDSATLIKRLKADGWELVHTVGSHHQFKHPSKRGKVTVPHPKKDLPLPTQNSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14446.24 Da        Isoelectric Point: 4.3479

>AT256879 WP_259432731.1 NZ_CP103872:3826993-3827397 [Herbaspirillum huttiense]
MLYPIYVHKDADSAYGAAFPDFPGCFAGADKLQDLPAAAQEAVEAHFHGETEPIPDPSVPEDWAGDEQFQGGYWMLVEID
LSRVNAKAVRLNVSLPQSLVARIDAVAQARRMSRSAFLALAAEHEMQAMAGGAT

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References