Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 298210..298862 Replicon chromosome
Accession NZ_CP103866
Organism Laceyella sacchari strain FBKL4.014

Toxin (Protein)


Gene name mazF Uniprot ID A0A7W2AID8
Locus tag NYR52_RS01630 Protein ID WP_022738671.1
Coordinates 298512..298862 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2I7SWQ4
Locus tag NYR52_RS01625 Protein ID WP_035952874.1
Coordinates 298210..298506 (+) Length 99 a.a.

Genomic Context

NYR52_RS01605NYR52_RS01610NYR52_RS01615NYR52_RS01620NYR52_RS01625NYR52_RS01630NYR52_RS01635NYR52_RS01640NYR52_RS01645NYR52_RS01650NYR52_RS01595NYR52_RS01600
Location: 294684..295067 (384 bp)
Type: Others
Protein ID: WP_132223502.1
Location: 295263..296291 (1029 bp)
Type: Others
Protein ID: WP_259436158.1
Location: 296410..296838 (429 bp)
Type: Others
Protein ID: WP_132223508.1
Location: 296843..298051 (1209 bp)
Type: Others
Protein ID: WP_259436159.1
Location: 298210..298506 (297 bp)
Type: Antitoxin
Protein ID: WP_035952874.1
Location: 298512..298862 (351 bp)
Type: Toxin
Protein ID: WP_022738671.1
Location: 299065..300069 (1005 bp)
Type: Others
Protein ID: WP_132223514.1
Location: 300092..300427 (336 bp)
Type: Others
Protein ID: WP_022738669.1
Location: 300424..300909 (486 bp)
Type: Others
Protein ID: WP_022738667.1
Location: 300875..301660 (786 bp)
Type: Others
Protein ID: WP_022738666.1
Location: 293701..294156 (456 bp)
Type: Others
Protein ID: WP_259436157.1
Location: 294209..294496 (288 bp)
Type: Others
Protein ID: WP_132223499.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NYR52_RS01595 (NYR52_01595)293701..294156-456WP_259436157.1DUF2269 domain-containing protein-
NYR52_RS01600 (NYR52_01600)294209..294496-288WP_132223499.1antibiotic biosynthesis monooxygenase family protein-
NYR52_RS01605 (NYR52_01605)294684..295067+384WP_132223502.1holo-ACP synthase-
NYR52_RS01610 (NYR52_01610)295263..296291+1029WP_259436158.1outer membrane lipoprotein carrier protein LolA-
NYR52_RS01615 (NYR52_01615)296410..296838+429WP_132223508.1hypothetical protein-
NYR52_RS01620 (NYR52_01620)296843..298051+1209WP_259436159.1alanine racemase-
NYR52_RS01625 (NYR52_01625)298210..298506+297WP_035952874.1ribbon-helix-helix protein, CopG familyAntitoxin
NYR52_RS01630 (NYR52_01630)298512..298862+351WP_022738671.1type II toxin-antitoxin system PemK/MazF family toxinToxin
NYR52_RS01635 (NYR52_01635)299065..300069+1005WP_132223514.1PP2C family protein-serine/threonine phosphatase-
NYR52_RS01640 (NYR52_01640)300092..300427+336WP_022738669.1STAS domain-containing protein-
NYR52_RS01645 (NYR52_01645)300424..300909+486WP_022738667.1anti-sigma B factor RsbW-
NYR52_RS01650 (NYR52_01650)300875..301660+786WP_022738666.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-50)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12912.98 Da        Isoelectric Point: 5.1224

>T256871 WP_022738671.1 NZ_CP103866:298512-298862 [Laceyella sacchari]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKAYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMSRVNEALMISLGMIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11347.24 Da        Isoelectric Point: 6.3443

>AT256871 WP_035952874.1 NZ_CP103866:298210-298506 [Laceyella sacchari]
MIGWGCFILSGTKRIMISLPTNLLQEVDGMVARDNSNRSEFIRQAMKMYLQERKKRLIREMMQRGYMEMARINLNIASEA
FVAEEEAEDTLDRLVSGV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7W2AID8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2I7SWQ4

References