Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4749335..4749973 Replicon chromosome
Accession NZ_CP103864
Organism Escherichia coli O157:H7 strain RV06

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NUE47_RS23395 Protein ID WP_000813794.1
Coordinates 4749797..4749973 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NUE47_RS23390 Protein ID WP_001270286.1
Coordinates 4749335..4749751 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE47_RS23370 (4744487) 4744487..4745428 - 942 WP_001251320.1 ABC transporter permease -
NUE47_RS23375 (4745429) 4745429..4746442 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
NUE47_RS23380 (4746460) 4746460..4747605 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
NUE47_RS23385 (4747850) 4747850..4749256 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
NUE47_RS23390 (4749335) 4749335..4749751 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NUE47_RS23395 (4749797) 4749797..4749973 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NUE47_RS23400 (4750195) 4750195..4750425 + 231 WP_000494244.1 YncJ family protein -
NUE47_RS23405 (4750517) 4750517..4752478 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NUE47_RS23410 (4752551) 4752551..4753087 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
NUE47_RS23415 (4753179) 4753179..4754351 + 1173 WP_001236316.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256863 WP_000813794.1 NZ_CP103864:c4749973-4749797 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256863 WP_001270286.1 NZ_CP103864:c4749751-4749335 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References