Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3811785..3812490 Replicon chromosome
Accession NZ_CP103864
Organism Escherichia coli O157:H7 strain RV06

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag NUE47_RS18320 Protein ID WP_000539519.1
Coordinates 3812104..3812490 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUE47_RS18315 Protein ID WP_001280945.1
Coordinates 3811785..3812114 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE47_RS18300 (3806942) 3806942..3807853 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
NUE47_RS18305 (3808031) 3808031..3810379 + 2349 WP_000950320.1 EAL domain-containing protein -
NUE47_RS18310 (3810387) 3810387..3811715 + 1329 WP_000086905.1 GGDEF domain-containing protein -
NUE47_RS18315 (3811785) 3811785..3812114 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NUE47_RS18320 (3812104) 3812104..3812490 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUE47_RS18325 (3812716) 3812716..3814041 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NUE47_RS18330 (3814254) 3814254..3814637 + 384 WP_000497137.1 biofilm formation regulator BssR -
NUE47_RS18335 (3814748) 3814748..3815863 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
NUE47_RS18340 (3815860) 3815860..3816486 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T256860 WP_000539519.1 NZ_CP103864:c3812490-3812104 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT256860 WP_001280945.1 NZ_CP103864:c3812114-3811785 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References