Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1580394..1581148 Replicon chromosome
Accession NZ_CP103864
Organism Escherichia coli O157:H7 strain RV06

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NUE47_RS07885 Protein ID WP_001301452.1
Coordinates 1580663..1581148 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag NUE47_RS07880 Protein ID WP_000801912.1
Coordinates 1580394..1580672 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE47_RS07875 (1577622) 1577622..1580327 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
NUE47_RS07880 (1580394) 1580394..1580672 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
NUE47_RS07885 (1580663) 1580663..1581148 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
NUE47_RS07890 (1581198) 1581198..1582226 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
NUE47_RS07895 (1582230) 1582230..1583456 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
NUE47_RS07900 (1583644) 1583644..1585242 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
NUE47_RS07905 (1585224) 1585224..1585982 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T256850 WP_001301452.1 NZ_CP103864:1580663-1581148 [Escherichia coli O157:H7]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT256850 WP_000801912.1 NZ_CP103864:1580394-1580672 [Escherichia coli O157:H7]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References