Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1037711..1038282 Replicon chromosome
Accession NZ_CP103863
Organism Enterococcus faecalis strain SJ82

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NYR15_RS05090 Protein ID WP_002354774.1
Coordinates 1037711..1038052 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag NYR15_RS05095 Protein ID WP_002354773.1
Coordinates 1038052..1038282 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR15_RS05085 (1033726) 1033726..1037340 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
NYR15_RS05090 (1037711) 1037711..1038052 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYR15_RS05095 (1038052) 1038052..1038282 - 231 WP_002354773.1 hypothetical protein Antitoxin
NYR15_RS05100 (1038457) 1038457..1038672 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NYR15_RS05105 (1038811) 1038811..1039803 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
NYR15_RS05110 (1040067) 1040067..1040696 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
NYR15_RS05115 (1041389) 1041389..1043005 + 1617 WP_104681241.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T256835 WP_002354774.1 NZ_CP103863:c1038052-1037711 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT256835 WP_002354773.1 NZ_CP103863:c1038282-1038052 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References