256827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 32419..33556 Replicon plasmid unnamed1
Accession NZ_CP103862
Organism Enterococcus faecalis strain SJ82

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NYR15_RS00210 Protein ID WP_002333003.1
Coordinates 32419..33282 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag NYR15_RS00215 Protein ID WP_002333002.1
Coordinates 33284..33556 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR15_RS00185 (27634) 27634..28218 + 585 WP_258077898.1 IS30 family transposase -
NYR15_RS00190 (28290) 28290..29903 - 1614 WP_002333004.1 hypothetical protein -
NYR15_RS00195 (29927) 29927..30808 - 882 WP_002326774.1 ABC transporter ATP-binding protein -
NYR15_RS00200 (31119) 31119..31715 + 597 WP_002326773.1 TetR/AcrR family transcriptional regulator -
NYR15_RS00205 (31884) 31884..32288 - 405 Protein_40 DnaJ domain-containing protein -
NYR15_RS00210 (32419) 32419..33282 - 864 WP_002333003.1 zeta toxin family protein Toxin
NYR15_RS00215 (33284) 33284..33556 - 273 WP_002333002.1 antitoxin Antitoxin
NYR15_RS00220 (33574) 33574..33789 - 216 WP_001835296.1 peptide-binding protein -
NYR15_RS00225 (33881) 33881..34777 - 897 WP_104681373.1 ParA family protein -
NYR15_RS00230 (34880) 34880..36715 - 1836 WP_232035937.1 type IA DNA topoisomerase -
NYR15_RS00235 (36933) 36933..37163 + 231 WP_181039775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / erm(B) / dfrG - 1..40153 40153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32365.76 Da        Isoelectric Point: 6.3643

>T256827 WP_002333003.1 NZ_CP103862:c33282-32419 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT256827 WP_002333002.1 NZ_CP103862:c33556-33284 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6BWJ3

References