256823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1054809..1055585 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NYR13_RS05495 Protein ID WP_000031108.1
Coordinates 1055433..1055585 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NYR13_RS05490 Protein ID WP_001251224.1
Coordinates 1054809..1055408 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS05470 (1050725) 1050725..1052182 + 1458 WP_000649907.1 ABC transporter permease subunit -
NYR13_RS05475 (1052175) 1052175..1052897 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NYR13_RS05480 (1053048) 1053048..1054175 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
NYR13_RS05485 (1054180) 1054180..1054650 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NYR13_RS05490 (1054809) 1054809..1055408 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NYR13_RS05495 (1055433) 1055433..1055585 + 153 WP_000031108.1 SAS053 family protein Toxin
NYR13_RS05500 (1056362) 1056362..1056757 + 396 WP_000901021.1 hypothetical protein -
NYR13_RS05505 (1056953) 1056953..1058338 + 1386 WP_000116224.1 class II fumarate hydratase -
NYR13_RS05510 (1058801) 1058801..1059622 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T256823 WP_000031108.1 NZ_CP103860:1055433-1055585 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT256823 WP_001251224.1 NZ_CP103860:1054809-1055408 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References