Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 854300..854829 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NYR13_RS04230 Protein ID WP_000621175.1
Coordinates 854467..854829 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NYR13_RS04225 Protein ID WP_000948331.1
Coordinates 854300..854470 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS04195 (849337) 849337..849897 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
NYR13_RS04200 (850105) 850105..850584 + 480 WP_001287088.1 hypothetical protein -
NYR13_RS04205 (850577) 850577..852160 + 1584 WP_001294626.1 PH domain-containing protein -
NYR13_RS04210 (852147) 852147..852638 + 492 WP_001205910.1 PH domain-containing protein -
NYR13_RS04215 (852642) 852642..853001 + 360 WP_000581200.1 holo-ACP synthase -
NYR13_RS04220 (853067) 853067..854215 + 1149 WP_001281145.1 alanine racemase -
NYR13_RS04225 (854300) 854300..854470 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NYR13_RS04230 (854467) 854467..854829 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYR13_RS04235 (855179) 855179..856180 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NYR13_RS04240 (856299) 856299..856625 + 327 WP_001052491.1 anti-sigma factor antagonist -
NYR13_RS04245 (856627) 856627..857106 + 480 WP_001190829.1 anti-sigma B factor RsbW -
NYR13_RS04250 (857081) 857081..857851 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T256819 WP_000621175.1 NZ_CP103860:854467-854829 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT256819 WP_000948331.1 NZ_CP103860:854300-854470 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References