Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 834559..835073 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NYR13_RS04140 Protein ID WP_000581792.1
Coordinates 834864..835073 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NYR13_RS04135 Protein ID WP_000138932.1
Coordinates 834559..834852 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS04115 (829822) 829822..830463 + 642 WP_000483153.1 thiamine phosphate synthase -
NYR13_RS04120 (830549) 830549..831421 + 873 WP_000725802.1 membrane protein insertase YidC -
NYR13_RS04125 (832234) 832234..832881 - 648 WP_001187629.1 HD domain-containing protein -
NYR13_RS04130 (832909) 832909..834393 - 1485 WP_000571549.1 cardiolipin synthase -
NYR13_RS04135 (834559) 834559..834852 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NYR13_RS04140 (834864) 834864..835073 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NYR13_RS04145 (835201) 835201..835338 + 138 WP_000828354.1 Lmo0850 family protein -
NYR13_RS04150 (835602) 835602..836804 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NYR13_RS04155 (837122) 837122..838192 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NYR13_RS04160 (838207) 838207..839565 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T256818 WP_000581792.1 NZ_CP103860:834864-835073 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT256818 WP_000138932.1 NZ_CP103860:834559-834852 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References