Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1975506..1977101 Replicon chromosome
Accession NZ_CP103852
Organism Ralstonia pseudosolanacearum strain LMG 9673

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NY025_RS17105 Protein ID WP_193025710.1
Coordinates 1975506..1976843 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NY025_RS17110 Protein ID WP_020749234.1
Coordinates 1976847..1977101 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY025_RS17080 (NY025_17080) 1971141..1971881 + 741 WP_193025714.1 protocatechuate 3,4-dioxygenase subunit beta -
NY025_RS17085 (NY025_17085) 1971878..1972576 + 699 WP_193034642.1 protocatechuate 3,4-dioxygenase subunit alpha -
NY025_RS17090 (NY025_17090) 1972724..1973320 + 597 WP_230642937.1 RNA 2',3'-cyclic phosphodiesterase -
NY025_RS17095 (NY025_17095) 1973353..1974081 - 729 WP_193034641.1 DsbA family protein -
NY025_RS17100 (NY025_17100) 1974307..1975509 - 1203 WP_193025711.1 MFS transporter -
NY025_RS17105 (NY025_17105) 1975506..1976843 - 1338 WP_193025710.1 type II toxin-antitoxin system HipA family toxin Toxin
NY025_RS17110 (NY025_17110) 1976847..1977101 - 255 WP_020749234.1 helix-turn-helix transcriptional regulator Antitoxin
NY025_RS17115 (NY025_17115) 1977205..1978044 - 840 WP_193025709.1 oxaloacetate decarboxylase -
NY025_RS17120 (NY025_17120) 1978199..1978369 + 171 WP_193025708.1 hypothetical protein -
NY025_RS17125 (NY025_17125) 1978366..1979004 + 639 WP_193025707.1 7-carboxy-7-deazaguanine synthase -
NY025_RS17130 (NY025_17130) 1979072..1979548 + 477 WP_193025706.1 6-carboxytetrahydropterin synthase QueD -
NY025_RS17135 (NY025_17135) 1979568..1980119 + 552 WP_193025705.1 tRNA adenosine(34) deaminase TadA -
NY025_RS17140 (NY025_17140) 1980116..1981042 + 927 WP_064049931.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1969368..1978369 9001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48831.87 Da        Isoelectric Point: 6.5034

>T256805 WP_193025710.1 NZ_CP103852:c1976843-1975506 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEPVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFSLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDALLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLTAWGLEVAHTEMARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRTCLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLTDIHLRHWQALAAQSGVPDAFAGMLALVE
RVPAGLDQVEAILPHDFSGRVWSSVRTGVLAQTERFLTELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8710.02 Da        Isoelectric Point: 10.4693

>AT256805 WP_020749234.1 NZ_CP103852:c1977101-1976847 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGGPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References