Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 444712..445345 Replicon chromosome
Accession NZ_CP103852
Organism Ralstonia pseudosolanacearum strain LMG 9673

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NY025_RS09850 Protein ID WP_193027353.1
Coordinates 444932..445345 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D8N529
Locus tag NY025_RS09845 Protein ID WP_020747258.1
Coordinates 444712..444945 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY025_RS09830 (NY025_09830) 440291..441586 - 1296 WP_193027348.1 MFS transporter -
NY025_RS09835 (NY025_09835) 441594..442826 - 1233 WP_193027350.1 AGE family epimerase/isomerase -
NY025_RS09840 (NY025_09840) 443048..444655 + 1608 WP_193028416.1 glucan biosynthesis protein -
NY025_RS09845 (NY025_09845) 444712..444945 + 234 WP_020747258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NY025_RS09850 (NY025_09850) 444932..445345 + 414 WP_193027353.1 PIN domain-containing protein Toxin
NY025_RS09855 (NY025_09855) 445320..445949 - 630 WP_193027355.1 DUF1415 family protein -
NY025_RS09860 (NY025_09860) 445993..447489 - 1497 WP_193027357.1 glycerol kinase GlpK -
NY025_RS09865 (NY025_09865) 447657..447884 - 228 Protein_414 carbohydrate ABC transporter substrate-binding protein -
NY025_RS09870 (NY025_09870) 447885..448007 - 123 Protein_415 ABC transporter -
NY025_RS09875 (NY025_09875) 448264..449841 - 1578 WP_193027360.1 glycerol-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15091.41 Da        Isoelectric Point: 5.5407

>T256802 WP_193027353.1 NZ_CP103852:444932-445345 [Ralstonia pseudosolanacearum]
MPATEAFFDSNVVLYLLSADAAKADTAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRIEPLTLET
HELGRRLAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVVEQHLRIVNPFSARA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8806.98 Da        Isoelectric Point: 8.7287

>AT256802 WP_020747258.1 NZ_CP103852:444712-444945 [Ralstonia pseudosolanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRSARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4TW23

References