Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 270378..271039 Replicon chromosome
Accession NZ_CP103852
Organism Ralstonia pseudosolanacearum strain LMG 9673

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NY025_RS09080 Protein ID WP_259423471.1
Coordinates 270378..270791 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D8N5P4
Locus tag NY025_RS09085 Protein ID WP_020749302.1
Coordinates 270788..271039 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY025_RS09045 (NY025_09045) 265890..266660 + 771 WP_259423464.1 hypothetical protein -
NY025_RS09050 (NY025_09050) 266669..267061 + 393 WP_197366558.1 hypothetical protein -
NY025_RS09055 (NY025_09055) 267112..267279 + 168 WP_230643730.1 hypothetical protein -
NY025_RS09060 (NY025_09060) 267254..267898 + 645 WP_259423467.1 DUF6441 family protein -
NY025_RS09065 (NY025_09065) 267941..268231 - 291 WP_064051869.1 H-NS family nucleoid-associated regulatory protein -
NY025_RS09070 (NY025_09070) 268426..269619 - 1194 WP_269436757.1 YopJ family acetyltransferase -
NY025_RS09075 (NY025_09075) 270176..270373 + 198 WP_230643628.1 DUF6441 family protein -
NY025_RS09080 (NY025_09080) 270378..270791 - 414 WP_259423471.1 type II toxin-antitoxin system VapC family toxin Toxin
NY025_RS09085 (NY025_09085) 270788..271039 - 252 WP_020749302.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NY025_RS09090 (NY025_09090) 271115..275215 + 4101 WP_259423473.1 tape measure protein -
NY025_RS09095 (NY025_09095) 275221..275616 + 396 WP_197366418.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 228152..284758 56606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15800.23 Da        Isoelectric Point: 6.2337

>T256801 WP_259423471.1 NZ_CP103852:c270791-270378 [Ralstonia pseudosolanacearum]
MSYLIDTNVLSELRRKQPDARVLAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAVRRQHLIDWLETELPNYFLGRLLDVD
AHTADRWGRLMSSANRPLPAIDGLLAATALQHDLILVTRNTKDFVGLDVPLINPWEM

Download         Length: 414 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9258.46 Da        Isoelectric Point: 5.0628

>AT256801 WP_020749302.1 NZ_CP103852:c271039-270788 [Ralstonia pseudosolanacearum]
MQSWQLQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGSGESLVDFMRQSPLAGLDDVVFERERSLPRE
VDF

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5B7U0Z6

References