Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2176049..2176563 Replicon chromosome
Accession NZ_CP103850
Organism Staphylococcus aureus strain NRL 02/947

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag NYF25_RS10850 Protein ID WP_259425915.1
Coordinates 2176049..2176258 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NYF25_RS10855 Protein ID WP_000138932.1
Coordinates 2176270..2176563 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF25_RS10830 (2171557) 2171557..2172915 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NYF25_RS10835 (2172930) 2172930..2174000 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NYF25_RS10840 (2174318) 2174318..2175520 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NYF25_RS10845 (2175784) 2175784..2175921 - 138 WP_000828354.1 Lmo0850 family protein -
NYF25_RS10850 (2176049) 2176049..2176258 - 210 WP_259425915.1 heavy metal-associated domain-containing protein Toxin
NYF25_RS10855 (2176270) 2176270..2176563 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NYF25_RS10860 (2176729) 2176729..2178213 + 1485 WP_000571549.1 cardiolipin synthase -
NYF25_RS10865 (2178241) 2178241..2178888 + 648 WP_001187629.1 HD domain-containing protein -
NYF25_RS10870 (2179701) 2179701..2180573 - 873 WP_000725802.1 membrane protein insertase YidC -
NYF25_RS10875 (2180659) 2180659..2181300 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7901.81 Da        Isoelectric Point: 4.0265

>T256794 WP_259425915.1 NZ_CP103850:c2176258-2176049 [Staphylococcus aureus]
MIHQNTIYTEGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT256794 WP_000138932.1 NZ_CP103850:c2176563-2176270 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References