Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2156293..2156822 Replicon chromosome
Accession NZ_CP103850
Organism Staphylococcus aureus strain NRL 02/947

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NYF25_RS10760 Protein ID WP_000621175.1
Coordinates 2156293..2156655 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NYF25_RS10765 Protein ID WP_000948331.1
Coordinates 2156652..2156822 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF25_RS10740 (2153271) 2153271..2154041 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
NYF25_RS10745 (2154016) 2154016..2154495 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NYF25_RS10750 (2154497) 2154497..2154823 - 327 WP_001052491.1 anti-sigma factor antagonist -
NYF25_RS10755 (2154942) 2154942..2155943 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NYF25_RS10760 (2156293) 2156293..2156655 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYF25_RS10765 (2156652) 2156652..2156822 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NYF25_RS10770 (2156907) 2156907..2158055 - 1149 WP_001281145.1 alanine racemase -
NYF25_RS10775 (2158121) 2158121..2158480 - 360 WP_000581200.1 holo-ACP synthase -
NYF25_RS10780 (2158484) 2158484..2158975 - 492 WP_001205910.1 PH domain-containing protein -
NYF25_RS10785 (2158962) 2158962..2160545 - 1584 WP_001294626.1 PH domain-containing protein -
NYF25_RS10790 (2160538) 2160538..2161017 - 480 WP_001287088.1 hypothetical protein -
NYF25_RS10795 (2161225) 2161225..2161785 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T256793 WP_000621175.1 NZ_CP103850:c2156655-2156293 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT256793 WP_000948331.1 NZ_CP103850:c2156822-2156652 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References