Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1930041..1930817 Replicon chromosome
Accession NZ_CP103850
Organism Staphylococcus aureus strain NRL 02/947

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NYF25_RS09350 Protein ID WP_000031108.1
Coordinates 1930041..1930193 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NYF25_RS09355 Protein ID WP_001251224.1
Coordinates 1930218..1930817 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF25_RS09335 (1926004) 1926004..1926825 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NYF25_RS09340 (1927288) 1927288..1928673 - 1386 WP_000116224.1 class II fumarate hydratase -
NYF25_RS09345 (1928869) 1928869..1929264 - 396 WP_000901021.1 hypothetical protein -
NYF25_RS09350 (1930041) 1930041..1930193 - 153 WP_000031108.1 SAS053 family protein Toxin
NYF25_RS09355 (1930218) 1930218..1930817 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NYF25_RS09360 (1930976) 1930976..1931446 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NYF25_RS09365 (1931451) 1931451..1932578 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
NYF25_RS09370 (1932729) 1932729..1933451 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NYF25_RS09375 (1933444) 1933444..1934901 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T256789 WP_000031108.1 NZ_CP103850:c1930193-1930041 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT256789 WP_001251224.1 NZ_CP103850:c1930817-1930218 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References