Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1569935..1570580 Replicon chromosome
Accession NZ_CP103834
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag NYR63_RS07225 Protein ID WP_279456935.1
Coordinates 1570209..1570580 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR63_RS07220 Protein ID WP_279456934.1
Coordinates 1569935..1570228 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR63_RS07190 (NYR63_07185) 1565262..1565945 - 684 WP_279456929.1 arginine ABC transporter permease ArtM -
NYR63_RS07195 (NYR63_07190) 1565945..1566616 - 672 WP_005598470.1 arginine ABC transporter permease ArtQ -
NYR63_RS07200 (NYR63_07195) 1566622..1567341 - 720 WP_279456930.1 transporter substrate-binding domain-containing protein -
NYR63_RS07205 (NYR63_07200) 1567362..1568096 - 735 WP_279456931.1 arginine ABC transporter ATP-binding protein ArtP -
NYR63_RS07210 (NYR63_07205) 1568326..1568823 - 498 WP_279456932.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR63_RS07215 (NYR63_07210) 1568896..1569858 + 963 WP_279456933.1 calcium/sodium antiporter -
NYR63_RS07220 (NYR63_07215) 1569935..1570228 - 294 WP_279456934.1 helix-turn-helix domain-containing protein Antitoxin
NYR63_RS07225 (NYR63_07220) 1570209..1570580 - 372 WP_279456935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR63_RS07230 (NYR63_07225) 1570782..1572530 + 1749 WP_279456936.1 protein-disulfide reductase DsbD -
NYR63_RS07235 (NYR63_07230) 1572590..1573159 + 570 WP_279456937.1 elongation factor P hydroxylase -
NYR63_RS07240 (NYR63_07235) 1573203..1574057 - 855 WP_279456938.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15024.49 Da        Isoelectric Point: 10.2796

>T256783 WP_279456935.1 NZ_CP103834:c1570580-1570209 [Actinobacillus genomosp. 1]
MYEIVFYRDKRGREPVKEFLLRLLKEQQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKNNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10940.92 Da        Isoelectric Point: 10.3120

>AT256783 WP_279456934.1 NZ_CP103834:c1570228-1569935 [Actinobacillus genomosp. 1]
MSPIGSSWTSFEQEIFDELEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKPKVPR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References