Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1476025..1476533 Replicon chromosome
Accession NZ_CP103834
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NYR63_RS06745 Protein ID WP_279456844.1
Coordinates 1476273..1476533 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NYR63_RS06740 Protein ID WP_279456843.1
Coordinates 1476025..1476276 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR63_RS06700 (NYR63_06695) 1471393..1471941 - 549 WP_279456840.1 type IV pilus biogenesis/stability protein PilW -
NYR63_RS06705 (NYR63_06700) 1471995..1473176 - 1182 WP_279456841.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
NYR63_RS06730 (NYR63_06725) 1474084..1475523 + 1440 WP_279456842.1 glutamate--tRNA ligase -
NYR63_RS06740 (NYR63_06735) 1476025..1476276 + 252 WP_279456843.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NYR63_RS06745 (NYR63_06740) 1476273..1476533 + 261 WP_279456844.1 Txe/YoeB family addiction module toxin Toxin
NYR63_RS06750 (NYR63_06745) 1476691..1476858 - 168 WP_279456845.1 Trm112 family protein -
NYR63_RS06755 (NYR63_06750) 1476860..1477840 - 981 WP_279456846.1 tetraacyldisaccharide 4'-kinase -
NYR63_RS06760 (NYR63_06755) 1477934..1479193 - 1260 WP_279456847.1 ATP-dependent protease ATP-binding subunit ClpX -
NYR63_RS06765 (NYR63_06760) 1479193..1479783 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
NYR63_RS06770 (NYR63_06765) 1479905..1480297 + 393 WP_279456848.1 SufE family protein -
NYR63_RS06785 (NYR63_06780) 1480655..1481428 - 774 WP_279456849.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10366.85 Da        Isoelectric Point: 7.1627

>T256782 WP_279456844.1 NZ_CP103834:1476273-1476533 [Actinobacillus genomosp. 1]
MKLTFSSNAWEDYLYWQKTDSIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9348.64 Da        Isoelectric Point: 4.5509

>AT256782 WP_279456843.1 NZ_CP103834:1476025-1476276 [Actinobacillus genomosp. 1]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERD
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References