Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 2223676..2224312 Replicon chromosome
Accession NZ_CP103833
Organism Actinobacillus arthritidis strain CCUG24862

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag NYR89_RS10700 Protein ID WP_279445790.1
Coordinates 2223941..2224312 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR89_RS10695 Protein ID WP_279445789.1
Coordinates 2223676..2223960 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR89_RS10665 (NYR89_10665) 2219059..2219742 - 684 WP_279445783.1 arginine ABC transporter permease ArtM -
NYR89_RS10670 (NYR89_10670) 2219742..2220413 - 672 WP_279445784.1 arginine ABC transporter permease ArtQ -
NYR89_RS10675 (NYR89_10675) 2220419..2221138 - 720 WP_279445785.1 transporter substrate-binding domain-containing protein -
NYR89_RS10680 (NYR89_10680) 2221158..2221892 - 735 WP_279445786.1 arginine ABC transporter ATP-binding protein ArtP -
NYR89_RS10685 (NYR89_10685) 2222089..2222586 - 498 WP_279445788.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR89_RS10690 (NYR89_10690) 2222660..2223621 + 962 Protein_2059 calcium/sodium antiporter -
NYR89_RS10695 (NYR89_10695) 2223676..2223960 - 285 WP_279445789.1 helix-turn-helix transcriptional regulator Antitoxin
NYR89_RS10700 (NYR89_10700) 2223941..2224312 - 372 WP_279445790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR89_RS10705 (NYR89_10705) 2224509..2226257 + 1749 Protein_2062 protein-disulfide reductase DsbD -
NYR89_RS10710 (NYR89_10710) 2226316..2226885 + 570 WP_279437970.1 elongation factor P hydroxylase -
NYR89_RS10715 (NYR89_10715) 2226929..2227781 - 853 Protein_2064 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14815.21 Da        Isoelectric Point: 10.2812

>T256781 WP_279445790.1 NZ_CP103833:c2224312-2223941 [Actinobacillus arthritidis]
MYEIVFYRDKRGREPVKESLLGLLKQSHNDNREKLQKISHHLSILHLHGTRAGENYIKHLEDRIWQIRPMSDCLLLTSII
RGQFVLLHYLAKSHYRIPKREIERAKSRLADLQARIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10435.21 Da        Isoelectric Point: 10.0168

>AT256781 WP_279445789.1 NZ_CP103833:c2223960-2223676 [Actinobacillus arthritidis]
MSPIGSSWHSFEQQVLNPLDIEEQNFRIKLILEIIETRQALGISQRKLESLSGVKQSMIARVEKGSSNPSLATLLKLLVP
LGKTLQIVPLNADK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References