Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2011505..2012236 Replicon chromosome
Accession NZ_CP103833
Organism Actinobacillus arthritidis strain CCUG24862

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NYR89_RS09610 Protein ID WP_279445628.1
Coordinates 2011505..2011972 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag NYR89_RS09620 Protein ID WP_279445630.1
Coordinates 2012072..2012236 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR89_RS09595 (NYR89_09595) 2007228..2009126 + 1899 WP_279445626.1 molecular chaperone DnaK -
NYR89_RS09600 (NYR89_09600) 2009357..2010498 + 1142 Protein_1851 molecular chaperone DnaJ -
NYR89_RS09605 (NYR89_09605) 2010541..2011422 - 882 WP_279445627.1 50S ribosomal protein L11 methyltransferase -
NYR89_RS09610 (NYR89_09610) 2011505..2011972 - 468 WP_279445628.1 GNAT family N-acetyltransferase Toxin
NYR89_RS09615 (NYR89_09615) 2011975..2012106 - 132 WP_279445629.1 DUF1778 domain-containing protein -
NYR89_RS09620 (NYR89_09620) 2012072..2012236 - 165 WP_279445630.1 DUF1778 domain-containing protein Antitoxin
NYR89_RS09625 (NYR89_09625) 2012357..2013816 - 1460 Protein_1856 metalloprotease TldD -
NYR89_RS09630 (NYR89_09630) 2013988..2015160 + 1173 WP_279445631.1 DNA-binding transcriptional regulator -
NYR89_RS09635 (NYR89_09635) 2015253..2016167 - 915 WP_279445632.1 N-acetylmuramic acid 6-phosphate etherase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-39)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17145.09 Da        Isoelectric Point: 9.2848

>T256780 WP_279445628.1 NZ_CP103833:c2011972-2011505 [Actinobacillus arthritidis]
MHAPESLSEQHIVRHFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDDNKQVMGFYCLSAGSVSRQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T256780 NZ_CP103833:c2011972-2011505 [Actinobacillus arthritidis]
ATGCATGCACCGGAGTCGCTTTCCGAGCAACATATTGTGCGACATTTTCAATGCGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGATAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGTCGTCAGTTTGTTGCAGGTGCATTAAGACGTAATATGCCCGATCCGATT
CCTGTGATTATTTTAGGTAGATTAGCTGTCGATTGTTCGGCACAAGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTAGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6202.28 Da        Isoelectric Point: 8.1156

>AT256780 WP_279445630.1 NZ_CP103833:c2012236-2012072 [Actinobacillus arthritidis]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQVCPKCDFRSYCFPIK

Download         Length: 165 bp

>AT256780 NZ_CP103833:c2012236-2012072 [Actinobacillus arthritidis]
ATGAGAACTGCACCAATTAATTTACGAGCGATGCCTGATCAACGTGATTTAATTGATTATGCGGCAAGTATTTTAGGTAA
AACTCGTTCTGACTTTATGTTAGAAACCGCATGCCAAGTTTGCCCAAAATGTGATTTTAGATCGTACTGTTTTCCAATTA
AATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References